MESvantage
Validated · ISO 13485 · 21 CFR Part 11

The manufacturing intelligence platform for medical device CDMOs.

Connect your ERP, your quality system, your CMMs and your machines into one validated platform. Built for regulated manufacturing. Live on your floor in 90 days.

90d
Time to Live
~70%
Faster Audit Prep
~75%
FAI Cycle Reduction
€0
Validation Budget
How it works

One platform, every system on your floor.

MESvantage sits at the centre of your manufacturing stack — ingesting data from ERP, quality, machines and metrology, and turning it into validated records, real-time intelligence, and customer-ready outputs.

YOUR INPUTS MESVANTAGE PLATFORM YOUR OUTPUTS ERP M1 · SAP · Plex · Infor · Oracle QMS Qualio · MasterControl · Greenlight Machines OPC-UA · MTConnect · Modbus CMMs Renishaw · Hexagon · Zeiss Documents OneDrive · SharePoint · Google Drive MESvantage VALIDATED PLATFORM CORE Device History Records (DHR) Genealogy & Traceability OEE & Downtime Intelligence FAI · Inspections · NCR · CAPA Scheduling & Standard Times Audit Trail & E-Signatures AI Executive Assistant OEM Customer Portals Lot release · DHR · Quality data Floor & Mobile PWA · Digital Signage · Operator UX Executive Intelligence Power BI · CEO dashboards Regulatory Packets IQ/OQ/PQ · Validation evidence SILOED SAAS · DEDICATED ENVIRONMENT PER CUSTOMER

Every customer runs in a fully isolated deployment. No shared compute, no shared databases, no cross-customer data — by design and by audit requirement.

The gap nobody else fills.

Purpose-built for CDMOs

Not a generic MES retrofitted to medical. Every workflow — DHR, FAI, CMM, OEE, NCR, lot release — was designed for regulated contract manufacturing from day one.

Validation transferable

IQ/OQ/PQ baseline already passed in a live regulated environment. Validation evidence transfers with the platform. Skip the 12-month validation programme.

Production-grade

Stress-tested at scale, 24/7, under FDA scrutiny. Every feature has run on a real production floor — not a lab, not a pilot, not a demo environment.

The platform

Real-time intelligence. Without the Excel.

See your shop floor the way your CEO wants to see it: live, drillable, audit-ready.

app.mesvantage.com / operations

Operations Dashboard

Live · Sample data · Updated 14:06

● Synced FDA 21 CFR Part 11
Output today
1,248
units · 96% target
OEE
78.4%
fleet-wide
FPY
99.2%
24h rolling
Open NCRs
3
1 awaiting CAPA
OEE — last 12 hours
Availability · Performance · Quality
02:0006:0010:0014:00
Cell status
Cell 01 ● Running
Cell 02 ● Running
Cell 03 ● Setup
Cell 04 ● Running
CMM Bay ● Idle

Sample data shown. Each MESvantage deployment runs in its own isolated environment.

Machine Intelligence

Every machine, every shift, every alert — predictive.

Live ingestion from OPC-UA, MTConnect and Modbus. ML models trained per machine class predict thermal drift, dimensional risk, and tool wear before they break a part — not after.

  • Real-time OEE per cell, work centre, and fleet
  • Thermal-drift prediction with 24-hour horizon
  • Auto-generated maintenance work orders
  • Closed-loop feedback to scheduling
  • Edge ML — no cloud round-trip required
app.mesvantage.com / machine-intel
Predictive alert. Cell 03 thermal drift trending. 73% probability of dimensional drift in next 4h. Maintenance scheduled 16:30.
Cell 01
PT-2049-B
● Running
84%
MTBF 18.4h · MTTR 22m
Cell 02
PT-2103-A
● Running
79%
MTBF 18.4h · MTTR 22m
Cell 03
PT-2049-B
● Setup
62%
MTBF 18.4h · MTTR 22m
Cell 04
PT-2210-C
● Running
88%
MTBF 18.4h · MTTR 22m
CMM-Bay-1
QC Queue
● Running
71%
MTBF 18.4h · MTTR 22m
VMC-09
● Idle
45%
MTBF 18.4h · MTTR 22m
app.mesvantage.com / assistant
Why did Cell 03 miss target this week?
M
Cell 03 hit 87.4% of target this week vs. fleet average 96.1%. Three contributing factors:
Cell 03 — Output vs. Target (this week)
target MTWTFSS
  1. Tool change overrun on Wed — operator Smith K. flagged thermal drift; 47min unscheduled stop.
  2. PT-2049-B setup time averaging 28% above Standard Time. Linked NCR NCR-1147 still open.
  3. Operator coverage — 3 shifts ran short by 1 trained operator (Qualio cert gap).
Recommendation
Approve recalibration WO #4892 (drafted) and schedule operator Patel R. for PT-2049-B graduation Thursday. Estimated recovery: +8.2 OEE pts next week.
OEE telemetryNCR-1147Standard TimesQualio trainingWO #4892
Ask anything about your floor… ⌘ K
Executive Assistant

Ask the question. Skip the dashboard.

A purpose-built LLM trained on your shop floor. It speaks DHR, FAI, NCR, OEE and ERP — and it cites every source. Auditors love it. Operators ask it everything.

  • Trained on your data, never co-mingled with another customer
  • Cites source records for every claim — audit-defensible
  • Drafts work orders, NCRs and CAPAs from natural-language requests
  • Available to every authorised role — operator to CEO
  • Runs in your isolated environment — your data never leaves
Genealogy & DHR

Every part. Every operation. Every signature.

Trace a single serial number from raw stock to OEM dispatch in two clicks. Audit-ready out of the box.

app.mesvantage.com / genealogy / SN-A4729-00184
Serial number
SN-A4729-00184
Part PT-2049-B · Lot LT-2026-Q2-018 · Released 12 May 2026
● Released to OEM FDA 21 CFR Part 11 DHR complete
08 May · 14:32
Lot received
Supplier SUP-217 · CoC verified · Incoming Qty 240
Receiving · auto
08 May · 16:15
Incoming inspection
Hardness ✓ · Surface ✓ · Dimensional ✓ · Sample n=8
Inspector Doyle M.
09 May · 09:00
First Article Inspection
CMM Renishaw EQUATOR · 32/32 features in tolerance · FAI-2026-0418
Inspector Patel R.
10 May · 14:22 → 15:45
Operation 010 — VMC turning
VMC-09 · Program PRG-2049-010-r4 · Tool offsets logged · Cycle 18m24s
Operator Smith K.
10 May · 16:00 → 17:30
Operation 020 — Mill & finish
Cell 03 · Program PRG-2049-020-r2 · Coolant Δ flagged · NCR-1147 raised
Operator Jones K.
11 May · 10:15
Dimensional CMM
Hexagon Global S · 18/18 features ✓ · Report HX-2026-1184
Inspector Patel R.
11 May · 13:42
Final inspection
Visual ✓ · Marking ✓ · Packaging ✓
Inspector Doyle M.
12 May · 09:14
DHR signed & locked
Electronic signature · Hash 0x9A4F…E218
QA Manager Walsh F.
12 May · 14:00
Released to OEM portal
Lot release packet generated · transmitted to customer portal
auto · MESvantage
Linked NCR · NCR-1147 9 e-signatures 2 CMM reports attached FAI-2026-0418 CoC available

50+ modules across 6 domains.

From incoming inspection to executive intelligence — everything a regulated CDMO needs in one validated platform.

Quality

FAI · FPY · SPC · DHR · NCR · CAPA · Incoming Inspection · Customer Quality Portal

Production

OEE · Scheduling · In-Process Documentation · Standard Times · Operator Graduation

Metrology

CMM integration with AI-powered parsing for Renishaw, Hexagon, and Zeiss

Training

Training enforcement, trainer/trainee context, operator-scoped access controls

Intelligence

CEO Dashboard · AI Executive Assistant · Energy Intelligence · Machine Intel

Platform

Mobile PWA · Digital Signage · Audit Trail · Electronic Signatures · RBAC · SSO

Ready to see it on your floor?

A 30-minute demo shows the full platform running against real manufacturing data, mapped to your stack.

Book a Demo